ART4 and central nervous system cancer: Figure 1 displays the TAPP mRNA profiles of the U251 and D54 glioma cells grown for 1 week under either hypoxic or normoxic conditions. We considered elevated levels of mRNA in the hypoxic glioma cells to occur when there was ≥1.9-fold expression over that displayed by the pair-matched normoxic controls. Figure 1A shows the profiles of TAPPs (Aim2, Art-4, EphA2, EZH2, Fosl1, PTH-rP, Sox11, Whsc2 and YKL-40) that were all elevated in the both glioma cell lines.