EPHA2 and central nervous system cancer: Many of the TAPP were not differentially expressed in the hypoxic cells but nine TAPPs from the glioma cells (Aim2, Art-4, EphA2, EZH2, Fosl1, PTH-rP, Sox11, Whsc2 and YKL-40) consistently exhibited increased mRNA presence after culturing the cells in response to hypoxia (Figure 1A).