[37]. Human glioma tissue was co-stained with either anti-Whsc2 or anti-YKL-40 antibodies (detected by red staining) to show co-localization within the same cells. Immunohistochemistry revealed a more invasive histology that is more characteristic of human clinical GBM. Figure S1 shows the invasiveness of this glioma more clearly in three peripheral locations (Panel A). Panel B shows a magnified region of one of the regions where infiltration is prominently observed. Figure 6 shows two-color immuno-fluorescent microscopy of a human glioma growing in situ. This evidence concerns the gene CHI3L1 and central nervous system cancer.