Nine TAPPs from the glioma cells (Aim2, Art-4, EphA2, EZH2, Fosl1, PTH-rP, Sox11, Whsc2 and YKL-40) consistently exhibited increased mRNA presence (≥1.9-fold expression) after culturing the cells in hypoxia (1% O2). Here, EZH2 is linked to central nervous system cancer.