HF had been demonstrated with accelerated bone loss and therefore osteoporosis and increased risk of hip fracture [1], [2], possibly attributed to either physical inactivity, increased loop diuretics use [7], similar comorbidities including renal disease, diabetes and altered neuroendocrine such as 25 hydroxyvitamin D [4], IL-1, IL-6 and TNF-alpha [3], [16]. The gene discussed is TNF; the disease is osteoporosis.