Liver is one of the most important organs that maintains blood glucose levels within normal limits thus enhancement of blood sugar yield to imbalance of oxidation-reduction reactions in hepatocytes, so that, hyperglycemia through increasing in AGEs (advanced glycation end products) facilities free radicals production via disturbance in ROS production (reactive oxygen species) such as SOD and CAT [57–59]. The gene discussed is SOD1; the disease is Hyperglycemia.