TNF and cervical squamous intraepithelial neoplasia: Although the −308G/A polymorphism of the TNF-α gene, especially the TNF2 allele, had been previously shown to contribute to increased serum levels of this cytokine in other disease entities [92, 93], no association was identified between this polymorphism with either the occurrence or the severity of neutropenia in CIN subjects [94, 95].