Interestingly though, out of three SNPs on the TGF-β1 gene, namely, the −509C/T, +869T/C, and the +915G/C, the −509C/T and specifically the T allele and the TT genotype occurred in a statistically higher frequency in CIN patients thus associating this genotype with the risk of development of CIN. This evidence concerns the gene TGFB1 and cervical squamous intraepithelial neoplasia.