Similar to AA, the pathogenetic cause of neutropenia in CIN is attributed to impaired BM granulopoiesis due to an inhibitory effect of the BM microenvironment consisting of activated T lymphocytes [83, 84] and monocytes [85], proinflammatory mediators, and proapoptotic cytokines such as TNF-α, IL-1β, TGF-β1, IL-6 as well as IFN-γ, and FasL [80, 83, 84]. The gene discussed is TNF; the disease is Decreased total neutrophil count.