ESR1 and Familial prostate cancer: In one study, variation in BNC2 (rs16934641) affected disease progression for patients treated with ADT for hormone sensitive disease, while variation in another estrogen receptor binding site related gene TACC2 (rs3763763) was associated with prostate cancer specific mortality, and variation in a third related gene ALPK1 (rs2051778) along with TACC2 (rs3763763) was associated with all-cause mortality in advanced stage disease [88].