RFC4 and breast carcinoma: For patients from the NKI breast cancer dataset with mixed subtypes as well as the lymph node-positive (LN+) cohort, Network 1 separated the good and poor outcome groups comparably well as the Van't Veer 70-gene signature [1] (Figure 4A–D), and both passed the p-value significance threshold after Bonferroni correction, despite the fact that the two lists only shared five genes in common (CENPA, MCM6, ORC6L, PRC1, RFC4).