For patients from the NKI breast cancer dataset with mixed subtypes as well as the lymph node-positive (LN+) cohort, Network 1 separated the good and poor outcome groups comparably well as the Van't Veer 70-gene signature [1] (Figure 4A–D), and both passed the p-value significance threshold after Bonferroni correction, despite the fact that the two lists only shared five genes in common (CENPA, MCM6, ORC6L, PRC1, RFC4). This evidence concerns the gene PRC1 and breast cancer.