CCT5 and hereditary sensory and autonomic neuropathy: Interestingly, Bouhouche et al65 reported a human pedigree in which a CCT5 mutation caused hereditary sensory neuropathy (Online Mendelian Inheritance in Man (OMIM) ID=610150), a syndrome characterised by a sensory deficit in the distal portion of the lower extremities, chronic perforating ulcerations of the feet and progressive destruction of underlying bones.