Specifically, a two-allele haplotype termed “G1” consisting of two non-synonymous coding variants rs73885319 (S342G) and rs60910145 (I384M) along with rs71785313—a 6 base pair deletion termed “G2” and close to G1 in exon 5 of APOL1 [10, 11]—is likely to account for the majority of risk of non-diabetic kidney disease associated with the variants in this region, but the role of MYH9 variants in non-diabetic kidney disease risk remains controversial [7]. The gene discussed is MYH9; the disease is diabetic kidney disease.