Several genes, e.g. ITGA3, ITGA5, CFL1, and RHOA, that were found to be selectively up regulated in CAFs derived from Her2+ but not ER + or TNBC breast cancers are known to be involved with pathways associated with integrin and RhoA signaling suggesting that CAFs may contribute to the invasiveness of Her2+ breast cancer[17]. This evidence concerns the gene RHOA and breast cancer.