PDP1 and neoplasm: The result is that tumor cells mobilize body stores in anabolic and glycolytic conditions, to build the tumor mass using body stores, the metabolic rewiring linked to the blockade of PK and PDH in tumor cells and in body stores is schematized in Figure 1B, in tumor cells PK and PDH are inactivated via PKA signals, while the other tumor enzymes are boosted via PKB.