However, sensitivity increased significantly for NAB combined with a cytological tumor marker compared with NAB alone (CYFRA 21–1: 94.4% versus 75.9%, p = 0.006, CEA: 87% versus 75.9%, p = 0.042, and SCC: 87% versus 75.9%, p = 0.042, respectively). This evidence concerns the gene CEACAM5 and neoplasm.