However, sensitivity increased significantly for NAB combined with cytological tumor markers compared with NAB alone (CYFRA 21–1: 95% versus 83.5%, p < 0.001, CEA: 92.1% versus 83.5%, p = 0.002, and SCC: 91.4% versus 83.5%, p = 0.003). This evidence concerns the gene CEACAM5 and neoplasm.