The significant decreased in the levels of malondialdehyde, glucose, insulin, and insulin resistance and increased in the levels of vitamins C and E, total antioxidant status, catalase, superoxide dismutase, glutathione peroxidase, and nitric oxide in the supplemented groups as compared with hypertensive control indicated the role of oxidative stress in hypertension, insulin resistance, and endothelial dysfunction in this model. The gene discussed is INS; the disease is endothelial dysfunction.