OPG was firstly discovered by Simonet in 1997 [8], which is one of the superfamily members of the tumor necrosis factor receptors, is a key factor in bone metabolism [8], [9].Recently, many studies also documented that OPG was a potential pro-angiogenic factor, which acts as an important factor in protecting vascular endothelial cells [10], [11], [12]., and discovered that OPG was involved in coronary heart disease [13], [14], high blood pressure [18] and peripheral artery diseases [19]. Here, TNFRSF11B is linked to peripheral arterial disease.