Most interestingly, low- and intermediate-1 risk MDS patients with abnormally lower PI of non-lymphoid CD34+ precursors and NRBC showed a significantly lower median OS -16 vs 132 (p = 0.03) and 15 vs 132 months (p = 0.001), respectively- and a higher risk of transformation to AL –median of 37 vs 135 (p = 0.005) and of 37 vs 135 months (p = 0.002), respectively- (Figure 2). Here, CD34 is linked to myelodysplastic syndrome.