These observations are in line with the more severe and numerous cytopenias found among the latter group of MDS patients, as well as with the hypermethylated status of cell cycle controlling genes (e.g.: p15INK4b, CDKN2B) reported to be associated with an enhanced hematopoiesis and neutrophil differentiation among specific subtypes of low-risk MDS (e.g.: RA with ringed sideroblasts) [32], [33], [34]. The gene discussed is CDKN2B; the disease is myelodysplastic syndrome.