In turn, a lower percentage of proliferating non-lymphoid CD34+ precursors (p = 0.001) and NRBC (p<0.001), together with the presence of thrombocytopenia (p = 0.001), ≥2 cytopenias (p = 0.01), transfusion dependency (p = 0.04) and higher IPSS or WPSS scores (p≤0.02), were also associated with a greater risk of transformation to AL (Figure 1 and Table 5). This evidence concerns the gene CD34 and Thrombocytopenia.