CD34 and myelodysplastic syndrome: The acquired secondary genetic alterations and hypermethylation patterns observed among CD34+ and maturing BM cells from advanced MDS [32], [36] might further lead to abnormal expression of genes associated with basic cell functions (e.g.: Ankaryn 1 and Tropomodulin in the erythroid lineage) [38], consequently contributing to a gradual defective capacity for multilineage proliferation and differentiation of BM precursors [24], [37].