FANCD2 and breast carcinoma: In our present study, gene silencing of FANCF in MCF-7 and T-47D breast cancer cells blocked the FA/BRCA pathway as evidenced by reducing the level of FANCD2 mono-ubiquitination, the loss of FANCD2 foci, inhibiting cell proliferation, promoting apoptosis and DNA damage (Fig. 1 and Fig. 2).