Nevertheless, it is noteworthy that the 30 to 50% growth inhibition of DU 145 and ME-180 cells in IGF-1-containing medium by Hex-hR1 was already comparable to the 25 to 50% growth inhibition of “drug-sensitive” NSCLC lines achieved with R1507, a representative ligand-blocking, antagonistic anti-IGF-1R human antibody [54]. This evidence concerns the gene IGF1 and non-small cell lung carcinoma.