NF1 and cancer: Among the ten genes, five of the TSGs (ATM, APC, BRCA2, NF1, and PTEN) were annotated with positive effects on apoptosis; the other three TSGs (PEG3, SPARC, and RPS6KA2) were also reported to increase apoptosis in sporadic epithelial OVC or other types of cancer [48], [49], [50].