LEF1 and cancer: For the nine added TF genes, seven of them were reported to take part in apoptosis in various types of cancer or diseases; these seven TFs are STAT3 [51], [52], [53], ETS1 [54], LEF1 [55], [56], STAT4 [57], E2F3 [58], ATF3 [59], and HMGA2 [60], which have not been annotated by GO yet.