The relative acceleration of tumour progression in response to Igf2 overexpression was also associated with a significant increase in Cyclin D1 expression in ΔCat;AdIgf2 when compared with ΔCat adrenals (Figure 4B, b), but did not result in further deregulation of malignancy markers expression (Figure S6 compared with Figure 3D). Here, IGF2 is linked to neoplasm.