One ACTH-treated ΔCat;AdIgf2 adrenal presented as an overt carcinoma in situ (Weiss 3) with diffuse architecture (Figure 4D, c) high grade nuclear alterations, oedematous remodelling (Figure 4D, f, dashed line) and large areas of necrosis (Figure 4D, f, inset). This evidence concerns the gene POMC and in situ carcinoma.