CCND1 and neoplasm: The relative acceleration of tumour progression in response to Igf2 overexpression was also associated with a significant increase in Cyclin D1 expression in ΔCat;AdIgf2 when compared with ΔCat adrenals (Figure 4B, b), but did not result in further deregulation of malignancy markers expression (Figure S6 compared with Figure 3D).