To expand on this study, and to confirm the relevance of the findings in human cancer models, we established doxycycline-inducible K-RAS shRNA expression in five K-RAS mutant human pancreatic cell lines (Capan-1, Panc 10.05, AsPC-1, L3.3 and PANC-1) (Table S1). Here, KRAS is linked to cancer.