In order to identify the gene(s) involved in this LOH region, we performed a fine-scale LOH analysis with 440 SNP markers located in 49 genes surrounding D4S2964 locus in 112 paired HCC and adjacent non-tumor liver tissues using a custom SNP microarray, and found a high frequency of LOH in HPSE gene [18]. Here, HPSE is linked to neoplasm.