HPSE and neoplasm: The univariate Cox regression analysis indicated that only HPSE mRNA level was significantly associated with overall survival in the subgroup of BCLC stage 0-A (P = 0.013, Table S8), and that HPSE protein expression score and tumor grade were significantly associated with overall survival in the subgroup of BCLC stage B–D (P = 0.011 and P = 0.022, respectively, Table S9).