They speculated that the inconsistent results from different reports on HPSE in HCC might be resulted from the different protein subcellular locations (nucleus, cytoplasm and cell surface), expression levels (low, moderate and high) and activities (enzymatic and non-enzymatic activities) of HPSE because it could have different effects in different sites, expression levels and activities [12]. Here, HPSE is linked to hepatocellular carcinoma.