The χ2 test indicated that the staining score of HPSE protein was significantly correlated with tumor grade (P = 0.012, Table 2), and that the correlation between HPSE protein expression and recurrence status was marginally significant as well (P = 0.056, Table 2), which suggests that HPSE expression might be significantly correlated with recurrence if the sample size was big enough. This evidence concerns the gene HPSE and neoplasm.