Correlation analysis between the LOH frequency of each SNP in HPSE gene and clinical features (serum AFP level, serum HBV-DNA level, HBsAg status, HBeAg status, tumor grade, tumor size, metastasis and recurrence) revealed that LOHs at three SNPs, rs4364254, rs6535458 and rs4568236, were significantly correlated with serum AFP level, tumor grade and serum HBV-DNA level (all P<0.05), respectively. This evidence concerns the gene HPSE and neoplasm.