The major goal in the present study was to address questions of whether cone bipolar cells could achieve regular mosaics and develop a mature dendritic and axonal morphology in the absence of normal synaptic inputs from cone photoreceptors, as well as the neuronal depletion pattern of cone bipolar cells soon after in the rd1 mouse model of RP. The gene discussed is PDE6B; the disease is retinitis pigmentosa 1.