We found a down-regulation of mRNA expression of HO-1 in renal tissue (Fig. 9A), as well as a decrease of plasma level of indirect bilirubin (Fig. 9B), a product of catabolism of toxic heme, TGF-β (Fig. 9C) and IL-10 (Fig. 9D) when compare with respective controls on day 0 after infection. The gene discussed is IL10; the disease is infection.