According to this, the main focus of this study was to evaluate how P. berghei ANKA infection affects or modifies kidney pathophysiology leading to cell injury, as well as the involvement of oxidative stress that occurs during plasmodium infection, determine the influence of renal endothelial modifications to development of malaria-associated AKI and also characterize how HO-1 may participate in both protection and pathogenesis of clinical outcome. Here, HMOX1 is linked to acute kidney injury.