NR1H4 and cholestasis: Although the exact role of FXR in regulating tissue homeostasis is not clear, FXR deficiency leads to development of various disease states such as hepatocellular carcinoma [28], [29], intestinal tumorigenesis [30]–[32], intestinal inflammation [24], [26], [33], cholestasis [34], nonalcoholic steatohepatitis (NASH) [35] and gall stone formation [36].