PRC1 and teratoma: [21] Other genes such as PHC1 and Uty were reported as epigenetic related genes. PHC1 is a component of the Polycomb group (PcG) multiprotein PRC1 complex, a complex required to maintain the transcriptionally repressive state of many genes throughout development including Hox genes. PcG PRC1 complex acts via chromatin remodeling and modification of histones. Uty is a gene that encodes a demethylase. This result is consistent with previous study that indicated epigenetic change played a crucial role in the development of teratoma [22], [23].