Several other genes involved in various functions, such as, hormonal response (AR, ESR1, ESR2, RARβ) cell cycle (CCND2, CDKN2A), tumor cell invasion (CAV1,CDH1,CDH13,LAMA3), and signal transduction (DAPK1, DAB2IP, RASSF1) are also affected by DNA hypermethylation in prostate cancer [27]. Here, CDH1 is linked to Familial prostate cancer.