Thus, using a model of dietary obese mice and euglycemic-hyperinsulinemic clamps to measure insulin sensitivity, we have demonstrated that the combined use of n-3 LC-PUFA and TZD rosiglitazone, both administered at a relatively low dose (a ‘combined intervention’), exerted synergistic effects in prevention as well as reversal of insulin resistance [14]. The gene discussed is INS; the disease is Insulin resistance.