INS and obesity due to melanocortin 4 receptor deficiency: Indeed, levels of several lysoPCs were decreased by the interventions, and the combined intervention tended to exert the strongest effect, in accordance with the notion that lysoPCs are associated with obesity-induced low-grade systemic inflammation (reviewed in [32]), and that phospholipase A2-derived lysoPC exert adverse effects on insulin responsiveness of myocytes [63].