NOTCH1 and pancreatic neoplasm: Moreover, we have also reported that CDF could function as a potential anti-tumor agent against human pancreatic tumor in vitro and in vivo mediated via regulation of miRNAs, CSC phenotype and function, and deregulation of multiple cellular signaling pathways such as NF-κB, Akt, COX-2, Notch-1, and EZH2 [22]–[24]; [57].