TOP2A and cancer: CDK1, up-regulated in five of the seven cancers studied, has been reported to be related to colon, prostate and stomach cancer, in view of its role in regulating the cell cycle, e.g. entry from G1 to S. TOP2A, again up-regulated in five of the seven cancers, has been reported to be associated with gastric [35], breast [36] and ovarian cancer [37], consistent with its function in DNA strand regulation.