Furthermore, in our study, which encompassed a relatively large number of gastric cancer patients (n = 410), we supported the hypothesis that AHRR acts as a tumor suppressor in gastric adenocarcinoma because low AHRR expression was associated with tumors with depth of tumor infiltration (T) (P<0.001), distant metastases (M) (P = 0.004) and TNM stage (P<0.001). This evidence concerns the gene AHRR and gastric adenocarcinoma.