To identify the function of HIF-1α and HIF-2α in hypoxia-induced expression of CX3CR1 in pancreatic cancer, we used three specific siRNAs targeting HIF-1α or HIF-2α and all of them effectively reduced HIF-1α or HIF-2α expression (Figure 1C). This evidence concerns the gene EPAS1 and familial pancreatic carcinoma.