For example, in breast cancer, PIK3R2 (phosphoinositide-3-kinase, regulatory subunit 2 beta) and ECT2 (epithelial cell transforming sequence 2 oncogene) have a TARGETgene rank of 37 and 272, and with a 3.31 and 4.94 fold change in gene expression of breast cancer tissues, respectively. This evidence concerns the gene PIK3R2 and breast cancer.