In this study, we observed that the phosphorylation of CaMKII and p38 MAPK was highly increased in both heart failure groups, shNC failure and shHRC failure, mediated by sustained pressure overload; however, the phosphorylation of CaMKII was more extensive in the shHRC failure group than it was in the shNC failure group, suggesting the increased activity of CaMKII in HRC-KD hearts (Figure 8). The gene discussed is CAMK2G; the disease is heart failure.