TNF and neoplasm: Exposure to mutiple inflammatory factors in the local microenvironment, such as interferon-γ (IFNγ), tumor necrosis factor-α (TNFα), and Interleukin-1 (IL-1), MSCs secrete several cytokines like Interleukin-10 (IL-10) [11], transforming growth factor-β (TGFβ) [11], [12], hepatocyte growth factor (HGF) [12], and vascular endothelial growth factor (VEGF) [13], which promote immunosuppression, angiogenesis and tumor growth.