Since signalling through TLR2 and TLR4 by hyaluronan may be important in the maintenance of epithelial integrity in the lung after inflammatory insults and in repair [30], it could be that TLR2 and TLR4 SNPs are also exhibiting effects in the inflammatory processes in COPD in order to down regulate detrimental signals. Here, TLR2 is linked to chronic obstructive pulmonary disease.