P2RX7 and bipolar disorder: P2RX7 has previously been associated with bipolar disorder, depression, anxiety disorders [38], [40], [41], [61], and cognitive symptoms in mania [15] and is believed to play a role in antidepressant action and causation of bipolar disorder by influencing neurotransmission [62], neuroprotection [63], and neuroinflammatory responses [64].