The expression of P2RX7 is high especially in the sub thalamic nucleus, hypothalamus and substantia nigra, all structures known to be associated with bipolar disorder (https://www.nextbio.com/b/search/ba/p2rx7?type=feature&id=19358).There is strong evidence that P2RX7 promotes excitatory neurotransmitter release at presynaptic sites from neurons [43]. This evidence concerns the gene P2RX7 and bipolar disorder.