WASF3 and neoplasm: The role of WAVE3 as a metastasis promoter gene is supported by the following observations: (i) WAVE3 is required and sufficient to drive cancer cell invasion and tumor metastasis [27]; (ii) the metastasis promoting activity of WAVE3 is further enhanced by phosphorylation downstream of Abl to regulate key aspects of cancer cell invasion, i.e., invadopodia and MMP activity [24]–[25] and (iii) WAVE3 expression is regulated by two microRNAs (miRs 200 and 31) [26], [33], which have been established as master regulators of EMT and invasion-metastasis cascade, respectively.