This result also establishes a direct association between WAVE3 expression levels in the circulating blood of BC patients and the risk of development of the metastatic disease, which led us to the next step where we sought to evaluate the prognostic value of WAVE3 expression levels in circulating tumor cells in women with operable breast cancer who have not yet developed metastatic BC at the time when the blood samples were collected. This evidence concerns the gene WASF3 and breast carcinoma.