Further insight in the mechanisms that connect transcriptional deregulation in cancer and metabolic abnormalities could be found if we bring to attention a set of genes, consisting in PRKAA2, PRKAB2, CREB1, MAP3K1, DUSP4, TLR3, JUN, UBE2V1, TLR2 and MEF2C. This evidence concerns the gene PRKAA2 and cancer.