In order to determine the relationship between caspase-9 and caspase-3 cascade, Sl-1 cells were infected by AfMNPV in the presence or absence of caspase-9 inhibitor (Z-LEHD-FMK) and caspase-3 activities were measured by a spectrofluoremeter at 10 h post-infection. This evidence concerns the gene CASP9 and infection.