C3 and dengue disease: A hallmark of severe dengue disease is the presence of elevated levels of cytokines and chemokines including IP-10, ITAC, IL-1β, IL-2, IL-6, IL-8, IL-10, IL-12, IL-13, TNFα, IFNα, IFNγ, MIF, RANTES, histamine, and complement proteins C3, C3a, and C5a within blood and tissues [1–3, 14–18].