VEGFA and renal cell carcinoma: The landscape for RCC treatment has changed dramatically in recent years, vascular endothelial growth factor (VEGF) receptor tyrosine phosphorylation inhibitors (TKIs) and drugs that inhibit mammalian target of rapamycin (mTOR) signaling have become the mainstay for the management of metastatic RCC based on improved progression-free survival or/and overall survival outcomes [6].