In our study, the effects of βig-H3 on OVCAR-5 cells were independent of the βig-H3 RGD integrin binding motif (amino acids 642–644), since treatment with ERGDEL peptide did not block the ability of βig-H3 to promote ovarian cancer cell motility, invasion, or adhesion to peritoneal cells. This evidence concerns the gene TGFBI and ovarian cancer.