In addition, it was previously reported that COX-1 [13], COX-2 [19] and cyclin D1 [20] were all up-regulated in ovarian cancer, and downregulation of cyclin D1 expression via a COX-2 dependent mechanism by celecoxib could be a potential mechanism to inhibit ovarian cancer growth [21]. The gene discussed is CCND1; the disease is ovarian cancer.