NFKB1 and nervous system disorder: As an established ROS-responsive transcription regulator NF-κB is up-regulated in virtually every human neurological disorder so far examined, so that besides anti-oxidant approaches, selective NF-kB inhibitors and specific chelators with innovative chelation or competition strategies may be useful to neutralize the initial effects of neurotoxic metal-sulfates in human brain cells [20,31–42].