For example, the tumor-associated endothelial cells showed increased chemoresistance compared to normal endothelial cells through the expression of PAX2 in renal carcinoma [48], the overexpression of survivin in a glioma model [49], and the activation of an NF-κB dependent pathway promoting Akt and VEGF expression and cell survival in hepatocellular carcinoma [50]. Here, VEGFA is linked to neoplasm.