VEGFA and Hyperglycemia: As it is well known, the main feature characterizing diabetes mellitus is hyperglycemia, which plays a pivotal role in the pathogenesis of diabetes vascular complications [12]: hyperglycemia, in particular, modifies VEGF synthesis and secretion in different cell types, such as glomerular podocytes [13], mesangial cells [14,15] and the retinal endothelial cells [16,17].