For instance, the data of the present study support the hypothesis that the effects of high glucose on VEGF in VSMC could be different in type 1 diabetes, which is mainly insulin deficient, and in type 2 diabetes, where a relative insulin deficiency is commonly accompanied by a profound insulin resistance, since the latter seems to attenuate the glucose effects on VEGF. This evidence concerns the gene VEGFA and type 2 diabetes mellitus.