We found the expression of EZH2 to be low or absent in benign nevi (Figure 6B and C), and EZH2 expression displayed progressive increase from benign nevi, dysplastic nevi, localized and metastatic melanoma samples (p-value =0.0015, =1.7E-16, =0.05 respectively) (Figure 6B and C). This evidence concerns the gene EZH2 and metastatic melanoma.