TNF and malaria: Additional file 1 also shows the family-based associations of SNPs with parasitaemia and mild malaria in individuals (n = 193), for which the level of IgG subclasses has been measured. HbC, LTA + 80, TNF-1031, TNF-238, TNF1304, and NCR3-412 were associated with parasitaemia or mild malaria in this sub-population ( Additional file 1). Moreover, FcγRIIa H/R131 was associated with mild malaria in individuals, for which the level of IgG2 was higher than the median ( Additional file 1).