Moreover, there was an association of low IgG3, IgG4, and IgG levels with TNF1304, which has been associated with mild malaria and parasitaemia in the same population [10]; this further supports the role of TNF1304 on malaria phenotypes, although the effect of the polymorphism on the molecular function or the gene expression has not been reported. The gene discussed is IGHG3; the disease is malaria.