A number of studies have reported a positive association between serum ALT levels and IR using indirect parameters such as the intravenous glucose tolerance test, (OR = 3.0 [95% CI 2.2-4.1]), and the homeostasis model assessment of insulin resistance [HOMA-IR, OR = 2.1 (1.5-2.9)][3,14]. This evidence concerns the gene GPT and Insulin resistance.