TβRII mutations occur in >90% of microsatellite unstable (MSI) colon cancers and most principally affect a polyadenine tract in exon 3 of TβRII, the BAT-RII; however, non-BAT point mutations in TβRII were found with less frequency also in microsatellite stable cancers[164,219]. Here, TGFBR2 is linked to colonic neoplasm.