Possibly, the loss of TβRII expression on the cell surface is the result of gene silencing by hypermehylation correlating to poor survival[277].TβRIII expression is diminished on mRNA and protein level in MM, enhancing cell growth, proliferation, mobility, heterotrophic cell–cell adhesion and contributing to disease progression[278]. This evidence concerns the gene TGFBR2 and Miyoshi myopathy.