Cross-sectional, retrospective and case series studies, which provide a lower level of evidence, suggest that CRP is of low diagnostic value for the diagnosis of several other infections, such as febrile urinary tract infections [10-13], acute febrile gastroenteritis [14], acute appendicitis [15], acute otitis media [16,17], community-acquired pneumonia [18], and meningitis [19]. The gene discussed is CRP; the disease is appendicitis.